The application of platinum complexes as anticancer agents motivated and pointed research of our group to the exploration of other active metal complexes in fight against cancer. Main objective in developing nonplatinum anticancer agents is to overcome a restricted range of activity, acquired primary and secondary resistance and severe toxicity. Nonplatinum metal-based compounds might demonstrate anticancer activity and toxic side-effects distinctly asort from platinum-based onces. They are expected to have different chemical behaviour, hydrolytic rates and mechanism(s) of action. The most prominent biologically active compounds were found to be those containing ruthenium, iridium, gold, gallium, titanium, tin and other metals.
Nanodrug delivery system
Current progress in nanostructured material synthesis and engineering has made a enormous influence on a number of fields including biomedical applications. Mesoporous particles of silicon dioxide are emerging as a new and promising class of nanoparticles that offers several attractive features for diagnostics and targeting of specific cell types in the context of drug delivery.